[Absence of increase of cyclic adenosine monophosphate (cAMP) in the cerebrospinal fluid of febrile patients (author's transl)].

Recent studies point toward the importance of cyclic adenosine 3',5'-monophosphate (cAMP) in the genesis of fever. Experimental fever induction in animals using bacterial pyrogens is accompanied with an increase of nucleotid concentration in the cerebrospinal fluid up to duplicate normal basal values. This aspect, however, has not been studied in human pathology. The concentration of cAMP in the cerebrospinal fluid of 11 patients with fever higher than 38.5 degrees C was studied. there were no significant differences between values found in these patients (14.03 +/- 5.82 pM/ml) and those corresponding to normality (15.44 +/- 3.36 pM/ml). We think that these results did not refute the role of cAMP in the pathogenesis of fever; they are only laboratory findings in discordance to experimental results.