Skorniakov V I, Kozhemiakin L A, Popov A S
Zh Vopr Neirokhir Im N N Burdenko. 1989 Jul-Aug(4):37-40.
The authors studied adenosine 3,5-cyclic monophosphate (cAMP) in the cerebrospinal fluid (csf) of patients with craniocerebral trauma (CCT), ischemic stroke, and brain tumors. A statistically significant increase of cAMP in csf of patients with moderate and severe CCT was revealed. In unfavourable outcomes of severe CCT the increase of cAMP continued to the time of death. The authors suggest using this index as a diagnostic criterion of the depth of the metabolic disorders in the brain tissue, as a prognostic criterion, and for purposes of differential diagnosis. The possible mechanism of lipid peroxidation activation in CCT is discussed.
作者研究了颅脑创伤（CCT）、缺血性中风和脑肿瘤患者脑脊液（CSF）中的3,5-环磷酸腺苷（cAMP）。结果显示，中度和重度CCT患者脑脊液中的cAMP有统计学意义的升高。在重度CCT的不良预后中，cAMP的升高一直持续到死亡时。作者建议将该指标用作脑组织代谢紊乱深度的诊断标准、预后标准以及鉴别诊断的依据。文中还讨论了CCT中脂质过氧化激活的可能机制。
