Hall E D
Psychiatry Res. 1980 Jul;2(3):241-50. doi: 10.1016/0165-1781(80)90016-5.
The ability of an intensive glucocorticoid regimen (i.e., triamcinolone diacetate, 8 mg/kg i.m./7 days) to modify the lumbar spinal monosynaptic reflex response to serotonergic and noradrenergic agents has been examined in unanesthetized acute spinal (C-1 sectioned) cats. Triamcinolone pretreatment enhances the 2N facilitatory actions of amitriptyline (AMIT), 5 mg/kg i.v., when given after D,L-5-hydroxytryptophan (5--HTP), 50 mg/kg i.v., as compared to untreated control preparations. Subsequent administration of methysergide, a serotonin receptor blocking drug, in a dose of 1 mg/kgh i.v. promptly and completely reverses the monosynaptic response increase by AMIT in untreated animals, but not in the glucocorticoid treated ones. In contrast, the monosynaptic facilitation normally produced in untreated preparations by methoxmine (MX), 1 mg/kg i.v., a centrally active noradrenergic agonist, is prevented as a result of triamcinolone dosing. These results demonstrate a glucocorticoid effect on spinal biogenic amine function such that serotonergic monosynaptic reflex activation is enhanced while noradrenergic reflex stimulation is depressed. Furthermore, they suggest that the elevations in plasma cortisol in certain cases of psychiatraic depression may; contribute to alterations in central biogenic amine synaptic activity.
在未麻醉的急性脊髓（C-1 节段切断）猫中，研究了强化糖皮质激素方案（即双醋酸曲安西龙，8 毫克/千克，肌肉注射，每 7 天一次）对腰脊髓单突触反射对血清素能和去甲肾上腺素能药物反应的影响。与未处理的对照制剂相比，双醋酸曲安西龙预处理增强了静脉注射 5 毫克/千克阿米替林（AMIT）在静脉注射 50 毫克/千克 D，L-5-羟色氨酸（5-HTP）后产生的 2N 促进作用。随后，静脉注射剂量为 1 毫克/千克的血清素受体阻断药物麦角新碱，可迅速且完全逆转未处理动物中 AMIT 引起的单突触反应增加，但在糖皮质激素处理的动物中则不然。相反，由于双醋酸曲安西龙给药，静脉注射 1 毫克/千克中枢活性去甲肾上腺素能激动剂甲氧明（MX）在未处理制剂中通常产生的单突触促进作用受到抑制。这些结果表明糖皮质激素对脊髓生物胺功能有影响，使得血清素能单突触反射激活增强，而去甲肾上腺素能反射刺激受到抑制。此外，它们表明在某些精神抑郁病例中血浆皮质醇升高可能有助于中枢生物胺突触活动的改变。
