Müller U, Bauknecht T, Siebers J W
Acta Endocrinol (Copenh). 1980 Jun;94(2):268-72. doi: 10.1530/acta.0.0940268.
The increase in the number of the ovarian LH/hCG-receptors and of serum progesterone concentration during pregnancy in the rat is highly dependent on the presence of prolactin during the luteinization process. Blocking of the hypophyseal prolactin secretion by twice daily injections of 2 microgram/g body weight bromocriptine into rats from the first day of pregnancy onwards prevents the increase in ovarian hCG-binding and progesterone production. Similar results are obtained by application of bromocriptine during the first three days only or either at day 1, 3 or 5 after mating. In all bromocriptine treated rats implantation of blastocysts does not occur. The failure to implant is not due to a teratogenic effect of bromocriptine onto preimplantation embryos, but is probably the consequence of changes of the uterine mucosa caused by the lack of progesterone production in the luteal cells.
大鼠孕期卵巢促黄体生成素/人绒毛膜促性腺激素（LH/hCG）受体数量及血清孕酮浓度的增加高度依赖于黄体化过程中催乳素的存在。从怀孕第一天起，每天给大鼠注射两次2微克/克体重的溴隐亭以阻断垂体催乳素分泌，可防止卵巢hCG结合能力及孕酮生成增加。仅在怀孕的前三天或交配后的第1、3或5天应用溴隐亭也可得到类似结果。在所有经溴隐亭处理的大鼠中，胚泡均未着床。着床失败并非由于溴隐亭对植入前胚胎的致畸作用，而可能是黄体细胞孕酮生成缺乏导致子宫黏膜变化的结果。
