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Prazosin protects vascular alpha-adrenoceptors against irreversible blockade by phenoxybenzamine.

作者信息

Greif J, Felix W

出版信息

Arch Int Pharmacodyn Ther. 1980 Mar;244(1):41-7.

PMID:6251765
Abstract

The interaction of prazosin with the vascular alpha-adrenoceptor was studied in isolated vessel preparations by means of receptor protection experiments. Prazosin was compared to phentolamine. Prazosin, like phentolamine protected the receptor against irreversible blockade by phenoxybenzamine. It is concluded that prazosin acts by a direct occupancy block of the vascular alpha-receptor.

摘要

相似文献

1
Prazosin protects vascular alpha-adrenoceptors against irreversible blockade by phenoxybenzamine.
Arch Int Pharmacodyn Ther. 1980 Mar;244(1):41-7.
2
The effects of prazosin, phentolamine and phenoxybenzamine on inhibitory alpha-adrenoceptors in the guniea-pig isolated ileum.哌唑嗪、酚妥拉明和酚苄明对豚鼠离体回肠中抑制性α-肾上腺素能受体的作用。
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3
Prazosin: differential affinities for two populations of alpha-noradrenergic receptor binding sites.哌唑嗪：对两类α-去甲肾上腺素能受体结合位点的不同亲和力。
Eur J Pharmacol. 1978 Jul 1;50(1):87-9. doi: 10.1016/0014-2999(78)90258-3.
4
The effect of beta-adrenoceptor antagonists on the alpha-adrenoceptor blockade produced by phenoxybenzamine.β-肾上腺素能受体拮抗剂对苯氧苄胺所致α-肾上腺素能受体阻断作用的影响。
Arch Int Pharmacodyn Ther. 1977 May;227(1):11-22.
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The effect of prazosin on the guinea-pig ileum.哌唑嗪对豚鼠回肠的作用。
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6
In vivo selectivity of prazosin but not of WB4101 for postsynaptic alpha-1 adrenoceptors.哌唑嗪对突触后α-1肾上腺素能受体具有体内选择性，而WB4101则没有。
J Pharmacol Exp Ther. 1981 May;217(2):467-74.
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The action of prazosin in human vascular preparations.
Arch Int Pharmacodyn Ther. 1978 Jan;231(1):81-9.
8
Classification of phenoxybenzamine/prazosin-resistant contractions of rat spleen to norepinephrine by Schild analysis: similarities and differences to postsynaptic alpha-2 adrenoceptors.通过Schild分析对大鼠脾脏对去甲肾上腺素的苯氧苄胺/哌唑嗪抗性收缩进行分类：与突触后α-2肾上腺素能受体的异同
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9
Effects of prazosin and phenoxybenzamine on alpha- and beta-receptor-mediated responses in intestinal resistance and capacitance vessels.哌唑嗪和酚苄明对肠道阻力血管和容量血管中α及β受体介导反应的影响。
J Cardiovasc Pharmacol. 1981 Sep-Oct;3(5):1050-9. doi: 10.1097/00005344-198109000-00015.
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Interaction of prazosin with alpha-adrenergic receptors--in vitro binding and in vivo antagonism.哌唑嗪与α-肾上腺素能受体的相互作用——体外结合与体内拮抗作用
Biochem Pharmacol. 1979 Aug 1;28(15):2409-11. doi: 10.1016/0006-2952(79)90711-1.

引用本文的文献

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Prazosin update. A review of its pharmacological properties and therapeutic use in hypertension and congestive heart failure.哌唑嗪最新进展。对其药理特性以及在高血压和充血性心力衰竭治疗中的应用综述。
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