Murthy A S, Vawter G F, Lee A B, Jockin H, Filler R M
Arch Pathol Lab Med. 1980 Oct;104(10):513-7.
Hepatoblastoma was associated with signs of isosexual precocity in an 11-month-old boy. Circulating gonadotropic hormone levels were elevated. Gonadotropic activity was demonstrated by bioassay in extracts of primary and metastatic tumor, and in media surrounding long-term tissue culture of the primary tumor. Morphology of the endocrine glands and bioassay of the pituitary gland obtained at autopsy indicated the presence of gonadotropins and other tropic hormones despite the physiologically abnormal hormone status. These ae the first direct studies of pituitary hormone content in this syndrome.
一名11个月大的男童患肝母细胞瘤，伴有同性性早熟体征。循环促性腺激素水平升高。通过生物测定法在原发性和转移性肿瘤提取物以及原发性肿瘤长期组织培养周围的培养基中证实了促性腺激素活性。尸检时获得的内分泌腺形态学和垂体生物测定表明，尽管激素状态生理异常，但仍存在促性腺激素和其他促激素。这些是对该综合征垂体激素含量的首次直接研究。
