碘化物对雌激素诱导的子宫过氧化物酶的影响。
Effect of iodide on estrogen-induced uterine peroxidase.
作者信息
Keeping H S, Jellinck P H
出版信息
Biochim Biophys Acta. 1980 Oct 1;632(2):150-8. doi: 10.1016/0304-4165(80)90072-0.
Iodide administered in the drinking water for 5-7 days increased the activity of estradiol-induced uterine peroxidase in the immature rat. This effect was specific for iodide and could not be mimickead by chloride, bromide, thiocyanate, perchlorate or iodate. Sodium iodide also increased peroxidase activity in the parotid gland but had no effect on glucose-6-phosphate dehydrogenase in the uterus, thyroid or parotid even though estradiol produced a 2-fold increase in the activity of this enzyme in the uterus. 125I was taken up more readily by the uterus than by muscle but this process was not influenced by prior treatment of the animals with estrogen. The in vitro effect of sulfhydryl reagents on uterine peroxidase was also investigated and proposals made for possible mechanisms of action of iodide on this enzyme in the intact animal.
在幼鼠饮用水中添加碘化物5至7天，可提高雌二醇诱导的子宫过氧化物酶的活性。这种作用对碘化物具有特异性，氯化物、溴化物、硫氰酸盐、高氯酸盐或碘酸盐无法模拟。碘化钠也可提高腮腺中过氧化物酶的活性，但对子宫、甲状腺或腮腺中的葡萄糖-6-磷酸脱氢酶没有影响，尽管雌二醇可使子宫中该酶的活性提高两倍。子宫比肌肉更容易摄取¹²⁵I，但该过程不受预先用雌激素处理动物的影响。还研究了巯基试剂对子宫过氧化物酶的体外作用，并提出了碘化物在完整动物体内对该酶可能的作用机制。
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