Lai F M, Tanikella T, Herzlinger H, Cervoni P
Eur J Pharmacol. 1980 Oct 3;67(1):97-9. doi: 10.1016/0014-2999(80)90013-8.
Intra-arterial injection of captopril (1 mg/kg) effectively lowered arterial blood pressure in aorta-coarcted hypertensive rats along with an associated reduction of serum angiotensin I-converting enzyme (ACE) activity. ACE activity in serum samples from captopril-treated animals that were assayed within 60 min after collection was inhibited 93%. However, this inhibition progressively decreased as the interval between time of assay and blood collection increased. This information would appear to be of considerable value in planning experiments for the determination of serum ACE activity from captopril-treated animals.
动脉内注射卡托普利（1毫克/千克）可有效降低主动脉缩窄性高血压大鼠的动脉血压，同时伴有血清血管紧张素I转换酶（ACE）活性降低。在采集后60分钟内测定的卡托普利治疗动物血清样本中的ACE活性被抑制了93%。然而，随着测定时间与采血时间间隔的增加，这种抑制作用逐渐减弱。这些信息对于规划从卡托普利治疗动物中测定血清ACE活性的实验似乎具有相当大的价值。
