The depletion of the granules of argentaffin and argyrophile cells of monkey duodenum by reserpine.

The influence of reserpine (5 mg/kg) on the argentaffin and argyrophile cells has been studied in 4 monkeys, and in 4 controls. In the treated animals, there is a marked and obvious reduction in the number of argentaffin cells; the cells that remain also show signs of partial depletion. Reduction of the number of argyrophile cells is not obvious on casual examination, but cell counts reveal a statistically significant reduction. The persisting argyrophile cells show signs of partial depletion.