Solntseva E I, Bulaev V M
Zh Evol Biokhim Fiziol. 1980 Sep-Oct;16(5):425-9.
Application of morphine and methionine-enkephaline using microionophoretic technique (20-100 nA, 1-15 sec) or perfusion (10(-7)--10(-6) M) caused inhibition of the impulsation, which in some of the cases was accompanied by hyperpolarization of the membrane and the decrease in its resistance, as well as by the reduction of EPSP's. The increase in impulsation with membrane depolarization was less frequent. beta-Endorphine (10(-7)--10(-6) M) caused a substantially longer inhibition of the impulse activity than morphine or met-enkephaline.
采用微离子电泳技术(20 - 100纳安,1 - 15秒)或灌流法(10⁻⁷ - 10⁻⁶摩尔)应用吗啡和甲硫氨酸脑啡肽会导致冲动发放受到抑制,在某些情况下还伴有膜超极化及其电阻降低,以及兴奋性突触后电位(EPSP)减小。随着膜去极化冲动发放增加的情况较少见。β-内啡肽(10⁻⁷ - 10⁻⁶摩尔)引起的冲动活动抑制比吗啡或甲硫氨酸脑啡肽持续时间长得多。