Reznik G, Stinson S F, Ward J M
Cancer Lett. 1980 Oct;10(4):339-42. doi: 10.1016/0304-3835(80)90051-8.
1,2-Dibromo-3-chloropropane (DBCP) was inhaled by B6C3F1 mice of each sex at concentrations of 0.6 or 3.0 ppm for 6 h/day, 5 days/week, for 103 weeks. Untreated controls consisted of 50 mice of each sex. All surviving animals were killed at 104 weeks. Survival in the high-dose groups of female mice was significantly shorter than that in the corresponding controls. Alveolar-bronchiolar adenomas or carcinomas occurred in both male and female mice with dose-related trends (P < 0.007) in males and (P < 0.002) in females. Papillary carcinomas in the lung occurred in low-dose female mice at an increased incidence compared with controls (P < 0.006). Many induced tumors were morphologically different than those in controls.
将1,2 - 二溴 - 3 - 氯丙烷（DBCP）以0.6或3.0 ppm的浓度让各性别B6C3F1小鼠吸入，每天6小时，每周5天，持续103周。未处理的对照组由各50只各性别的小鼠组成。所有存活的动物在104周时处死。高剂量组雌性小鼠的生存期显著短于相应的对照组。雄性和雌性小鼠均出现肺泡 - 细支气管腺瘤或癌，雄性呈现剂量相关趋势（P < 0.007），雌性呈现剂量相关趋势（P < 0.002）。低剂量雌性小鼠肺部乳头状癌的发生率高于对照组（P < 0.006）。许多诱发肿瘤在形态上与对照组不同。
