Bullier J, Henry G H
J Comp Neurol. 1980 Oct 15;193(4):913-35. doi: 10.1002/cne.901930407.
From the extracellular recording of single units in the monkey striate cortex and electrical stimulation at two selected sites in the optic radiations it was possible to estimate 1) the ordinal position of striate neurons (i.e., whether they received a monosynaptic, disynaptic or polysynaptic input from the thalamus) and 2) the nature of the afferent input to these neurons (i.e., whether it came from the magnocellular or parvocellular subdivision of the lateral geniculate nucleus (LGN)). Based on receptive field properties six major classes of striate neuron were identified--three which lacked orientation specificity (the ON-center, the OFF-center, and the ON/OFF or nonoriented (N-0) receptive fields) and three with orientation specific responses (the S, the C, and the B categories of receptive field). Units lacking orientation specificity were concentrated in laminae 4A, 4C beta and 6 while, for the cells with orientation specificity, C cells were found in laminae 4B and 6, B cells in 2/3 and 5, and S cells predominantly in laminae 2/3, 4C alpha, and 5. The results of electrical stimulation indicated that cell-to-cell transmission time in the monkey striate cortex is 1.5 msec, and latency measures showed that cells with a monosynaptic drive from the thalamus were confined to laminae 4 and 6 while disynaptically driven cells were found principally in upper lamina 4 (4A and 4B). No cell class was identified exclusively with a given ordinal position and there were many types of potential first-order neurons. The conduction time from one stimulating electrode to the next in the optic radiation was used to identify the afferent input to each striate neuron. The input to color-coded neurones was found to come exclusively from parvocellular layers while the C cells and two subclasses of the S cell (S2 and S3) were driven predominantly by the magnocellular subdivision. For other cell types (those with ON-center, N-0, and S1 receptive fields) the input came from either type of LGN neuron. The laminar distribution of neurons receiving a direct input from the magnocellular and parvocellular streams is in accord with the results of anatomical studies into the site of termination of the LGN input. The cell types receiving these direct inputs vary in the two streams so that the parvocellular input terminates on cells with ON-center and N-0 receptive fields in lamina 4C beta while the magnocellular input goes to cells with S, ON-center, N-0, and C receptive fields in lamina 4C alpha and the lower part of 4B. Consideration is given to the influence of these results on models for neural processing in monkey striate cortex and a comparison is drawn with the results of similar studies in the cat.
通过对猴纹状皮层单个神经元的细胞外记录以及对视辐射中两个选定部位的电刺激，可以估计：1）纹状神经元的序数位置（即它们是否从丘脑接受单突触、双突触或多突触输入）；2）这些神经元传入输入的性质（即它是来自外侧膝状体核（LGN）的大细胞或小细胞细分）。根据感受野特性，确定了六种主要的纹状神经元类别——三种缺乏方向特异性（ON中心、OFF中心以及ON/OFF或无方向（N-0）感受野），三种具有方向特异性反应（S、C和B类感受野）。缺乏方向特异性的神经元集中在第4A层、4Cβ层和第6层，而对于具有方向特异性的细胞，C细胞见于第4B层和第6层，B细胞见于第2/3层和第5层，S细胞主要见于第2/3层、4Cα层和第5层。电刺激结果表明，猴纹状皮层中的细胞间传递时间为1.5毫秒，潜伏期测量显示，从丘脑接受单突触驱动的细胞局限于第4层和第6层，而双突触驱动的细胞主要见于上部第4层（4A和4B）。没有一个细胞类别仅与给定的序数位置相关，并且有许多类型的潜在一级神经元。视辐射中从一个刺激电极到下一个刺激电极的传导时间用于确定每个纹状神经元的传入输入。发现颜色编码神经元的输入仅来自小细胞层，而C细胞和S细胞的两个亚类（S2和S3）主要由大细胞细分驱动。对于其他细胞类型（具有ON中心、N-0和S1感受野的细胞），输入来自LGN的任何一种神经元类型。接受来自大细胞和小细胞流直接输入的神经元的层状分布与对LGN输入终止部位的解剖学研究结果一致。接受这些直接输入的细胞类型在两个流中有所不同，因此小细胞输入终止于第4Cβ层中具有ON中心和N-0感受野的细胞，而大细胞输入则到达第4Cα层和4B下部中具有S、ON中心、N-0和C感受野的细胞。文中考虑了这些结果对猴纹状皮层神经处理模型的影响，并与猫的类似研究结果进行了比较。
