Millar J A, Hammat M T, Johnston C I
J Endocrinol. 1980 Aug;86(2):329-35. doi: 10.1677/joe.0.0860329.
Angiotensin II exerts an inhibitory influence on active renin release from the kidney. To assess a possible role for angiotensin II in the release of inactive renin, levels in the circulation were measured before and at regular intervals after the administration of captopril, an orally active inhibitor of angiotensin I-coverting enzyme, to 12 salt-replete and six salt-deplete normal subjects. Concurrent measurements of active renin, angiotensin I and angiotensin II were also performed. Basal inactive renin in the salt-deplete group was increased compared with the salt-replete subjects, but inactive renin remained constant in both groups after treatment with captopril. There were significant increases in concentrations of both active renin and angiotensin I after treatment with captopril in all subject and corresponding decreases in angiotensin II. These results suggested that angiotensin II does not influence the release of inactive renin, in contrast with its role in the release of active renin.
血管紧张素II对肾脏中活性肾素的释放具有抑制作用。为了评估血管紧张素II在无活性肾素释放中可能发挥的作用，对12名钠充足和6名钠缺乏的正常受试者口服活性血管紧张素I转换酶抑制剂卡托普利，并在给药前及给药后定期测量其循环中的无活性肾素水平。同时还对活性肾素、血管紧张素I和血管紧张素II进行了测量。与钠充足的受试者相比，钠缺乏组的基础无活性肾素有所增加，但在卡托普利治疗后，两组的无活性肾素均保持稳定。在所有受试者中，卡托普利治疗后活性肾素和血管紧张素I的浓度均显著升高，而血管紧张素II相应降低。这些结果表明，与血管紧张素II在活性肾素释放中的作用相反，它对无活性肾素的释放没有影响。
