Hadlow W J, Cheville N F, Jellison W L
J Wildl Dis. 1980 Apr;16(2):305-12. doi: 10.7589/0090-3558-16.2.305.
The presence of pox in a northern fur seal pup, Callorhinus ursinus, examined at necropsy on the Pribilof Islands, Alaska, 13 September 1951 was confirmed by re-examination of formalin-fixed tissues collected at that time. The disease was characterized by multiple 3 to 8 mm modules in the skin of the nose and flippers. Unlike pox lesions in other pinnipeds studied so far, the nodules were discrete dermal epitheliomas free of any direct connections with the overlying atrophic epidermis. They most likely arose from outer sheath cells of hair follicles. The tightly packed epithelial cells forming the nodules contained large, round, eosinophilic, intracytoplasmic inclusion bodies. As demonstrated by electron microscopy nearly 27 years after the tissues were fixed in formalin, poxvirus virions also were present in these cells. These findings indicate pox was present in a northern fur seal, hitherto undescribed in that species, 18 years before the disease was first reported in pinnipeds.
1951年9月13日在阿拉斯加普里比洛夫群岛对一只北海狗幼崽（海狗属）进行尸检时发现其身上有痘疹，当时采集的福尔马林固定组织经重新检查得到了证实。该病的特征是在鼻子和鳍状肢的皮肤上有多个3至8毫米的结节。与迄今为止研究的其他鳍足类动物的痘疹病变不同，这些结节是离散的皮肤上皮瘤，与上方萎缩的表皮没有任何直接联系。它们很可能起源于毛囊的外鞘细胞。形成结节的紧密排列的上皮细胞含有大的、圆形的、嗜酸性的胞质内包涵体。正如在组织用福尔马林固定近27年后通过电子显微镜所显示的那样，这些细胞中也存在痘病毒粒子。这些发现表明，在鳍足类动物首次报告该疾病的18年前，北海狗身上就存在痘疹，此前该物种中未曾描述过这种情况。
