• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
DNA methylation and the frequency of CpG in animal DNA.DNA甲基化与动物DNA中CpG的频率
Nucleic Acids Res. 1980 Apr 11;8(7):1499-504. doi: 10.1093/nar/8.7.1499.
2
Methylation pattern of mouse mitochondrial DNA.小鼠线粒体DNA的甲基化模式
Nucleic Acids Res. 1984 Jun 25;12(12):4811-24. doi: 10.1093/nar/12.12.4811.
3
Restriction sites containing CpG show a higher frequency of polymorphism in human DNA.含有CpG的限制性酶切位点在人类DNA中显示出更高的多态性频率。
Cell. 1984 Jan;36(1):131-8. doi: 10.1016/0092-8674(84)90081-3.
4
Frog virus 3 DNA is heavily methylated at CpG sequences.蛙病毒3 DNA在CpG序列处高度甲基化。
Virology. 1980 Nov;107(1):250-7. doi: 10.1016/0042-6822(80)90290-1.
5
DNA methylation in the fungi.真菌中的DNA甲基化。
J Biol Chem. 1984 Jul 10;259(13):8033-6.
6
Cleavage of methylated CCCGGG sequences containing either N4-methylcytosine or 5-methylcytosine with MspI, HpaII, SmaI, XmaI and Cfr9I restriction endonucleases.使用MspI、HpaII、SmaI、XmaI和Cfr9I限制性内切酶切割含有N4-甲基胞嘧啶或5-甲基胞嘧啶的甲基化CCCGGG序列。
Nucleic Acids Res. 1987 Sep 11;15(17):7091-102. doi: 10.1093/nar/15.17.7091.
7
DNA methylation and mutation.DNA甲基化与突变。
Mutat Res. 1993 Jan;285(1):61-7. doi: 10.1016/0027-5107(93)90052-h.
8
5-Methylcytosine in eukaryotic DNA.真核生物DNA中的5-甲基胞嘧啶。
Science. 1981 Jun 19;212(4501):1350-7. doi: 10.1126/science.6262918.
9
Restriction analysis and quantitative estimation of methylated bases of filamentous and unicellular cyanobacterial DNAs.丝状和单细胞蓝藻DNA的甲基化碱基的限制性分析和定量估计
J Bacteriol. 1988 Apr;170(4):1934-9. doi: 10.1128/jb.170.4.1934-1939.1988.
10
[5-Methylcytosine in pyrimidine sequences of plant and animal DNA: specificity of methylation].[植物和动物DNA嘧啶序列中的5-甲基胞嘧啶：甲基化特异性]
Biokhimiia. 1981 Aug;46(8):1458-74.

引用本文的文献

1
Epigenome-wide association study of placental co-methylated regions in newborns for prenatal opioid exposure.新生儿胎盘共甲基化区域与产前阿片类药物暴露的全表观基因组关联研究。
Environ Epigenet. 2025 Sep 4;11(1):dvaf021. doi: 10.1093/eep/dvaf021. eCollection 2025.
2
Mechanisms underlying low mutation rates in mammalian oocytes and preimplantation embryos.哺乳动物卵母细胞和植入前胚胎低突变率的潜在机制。
Nucleic Acids Res. 2025 Aug 11;53(15). doi: 10.1093/nar/gkaf760.
3
Protective effect of exercise on metabolic dysfunction‑associated fatty liver disease: Potential epigenetic mechanisms (Review).运动对代谢功能障碍相关脂肪性肝病的保护作用：潜在的表观遗传机制（综述）
Int J Mol Med. 2025 Oct;56(4). doi: 10.3892/ijmm.2025.5587. Epub 2025 Jul 19.
4
Whole genome DNA methylation patterns in tissue and cfDNA associated with fibrosis reflect the complex signature of MASLD.与纤维化相关的组织和循环游离DNA中的全基因组DNA甲基化模式反映了代谢相关脂肪性肝病的复杂特征。
PLoS One. 2025 Jul 17;20(7):e0328207. doi: 10.1371/journal.pone.0328207. eCollection 2025.
5
Methylation-associated mutagenesis underlies variation in the mutation spectrum across eukaryotes.甲基化相关的诱变作用是真核生物突变谱变异的基础。
bioRxiv. 2025 May 30:2025.05.28.656604. doi: 10.1101/2025.05.28.656604.
6
Impact of the Zinc Antiviral Protein on the Genomic Composition of RNA Viruses Infecting Vertebrates.锌抗病毒蛋白对感染脊椎动物的RNA病毒基因组组成的影响。
Mol Biol Evol. 2025 Jun 4;42(6). doi: 10.1093/molbev/msaf135.
7
Postnatal Epigenetic Alterations in Calves Persistently Infected with Bovine Viral Diarrhea Virus.持续感染牛病毒性腹泻病毒的犊牛的产后表观遗传改变
Viruses. 2025 May 15;17(5):708. doi: 10.3390/v17050708.
8
Germline mutation rates and fine-scale recombination parameters in zebra finch.斑胸草雀的种系突变率和精细尺度重组参数
PLoS Genet. 2025 Apr 15;21(4):e1011661. doi: 10.1371/journal.pgen.1011661. eCollection 2025 Apr.
9
TF Profiler: a transcription factor inference method that broadly measures transcription factor activity and identifies mechanistically distinct networks.转录因子分析器：一种广泛测量转录因子活性并识别机制上不同网络的转录因子推断方法。
Genome Biol. 2025 Apr 9;26(1):92. doi: 10.1186/s13059-025-03545-2.
10
Epigenetics in Skin Homeostasis and Ageing.皮肤稳态与衰老中的表观遗传学
Epigenomes. 2025 Jan 9;9(1):3. doi: 10.3390/epigenomes9010003.

本文引用的文献

1
Composition of the desoxypentose nucleic acids of four genera of sea-urchin.四种海胆属动物的脱氧戊糖核酸的组成
J Biol Chem. 1952 Mar;195(1):155-60.
2
The purine and pyrimidine composition of deoxypentose nucleic acids.脱氧戊糖核酸的嘌呤和嘧啶组成。
Biochem J. 1951 May;48(5):584-90. doi: 10.1042/bj0480584.
3
Enzymatic synthesis of deoxyribonucleic acid. XI. Further studies on nearest neighbor base sequences in deoxyribonucleic acids.脱氧核糖核酸的酶促合成。十一。对脱氧核糖核酸中相邻碱基序列的进一步研究。
J Biol Chem. 1962 Jun;237:1961-7.
4
Enzymatic synthesis of deoxyribonucleic acid. VIII. Frequencies of nearest neighbor base sequences in deoxyribonucleic acid.脱氧核糖核酸的酶促合成。VIII. 脱氧核糖核酸中相邻碱基序列的频率
J Biol Chem. 1961 Mar;236:864-75.
5
Sequence heterogeneity of 5 S RNA in Xenopus laevis.非洲爪蟾5S RNA的序列异质性
FEBS Lett. 1972 Sep 1;25(1):13-20. doi: 10.1016/0014-5793(72)80443-5.
6
The nucleotide sequence of somatic 5 S RNA from Xenopus laevis.非洲爪蟾体细胞5 S RNA的核苷酸序列。
FEBS Lett. 1972 Sep 1;25(1):8-12. doi: 10.1016/0014-5793(72)80442-3.
7
Variable patterns of total DNA and rDNA methylation in animals.动物中总DNA和核糖体DNA甲基化的可变模式。
Nucleic Acids Res. 1980 Apr 11;8(7):1485-97. doi: 10.1093/nar/8.7.1485.
8
An approach to evolutionary relationships of mammalian DNA viruses through analysis of the pattern of nearest neighbor base sequences.通过分析最近邻碱基序列模式研究哺乳动物DNA病毒进化关系的方法。
Cold Spring Harb Symp Quant Biol. 1966;31:737-48. doi: 10.1101/sqb.1966.031.01.094.
9
The heterogeneity of thymine methyl group origin in DNA pyrimidine isostichs of developing sea urchin embryos.发育中的海胆胚胎DNA嘧啶同列线中胸腺嘧啶甲基基团来源的异质性。
Proc Natl Acad Sci U S A. 1967 May;57(5):1394-400. doi: 10.1073/pnas.57.5.1394.
10
Different sequences for 5S RNA in kidney cells and ovaries of Xenopus laevis.非洲爪蟾肾细胞和卵巢中5S RNA的不同序列。
Nat New Biol. 1973 Jan 3;241(105):7-12. doi: 10.1038/newbio241007a0.

DNA甲基化与动物DNA中CpG的频率

DNA methylation and the frequency of CpG in animal DNA.

作者信息

Bird A P

出版信息

Nucleic Acids Res. 1980 Apr 11;8(7):1499-504. doi: 10.1093/nar/8.7.1499.

DOI:10.1093/nar/8.7.1499
PMID:6253938
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC324012/
Abstract

An analysis of nearest neighbour dinucleotide frequencies and the level of DNA methylation in animals strongly supports the suggestion that 5-methylcytosine (5mC) tends to mutate abnormally frequently to T. This tendency is the likely cause of the CpG deficiency in heavily methylated genomes.

摘要

对动物中最近邻二核苷酸频率和DNA甲基化水平的分析有力地支持了以下观点：5-甲基胞嘧啶（5mC）往往异常频繁地突变为胸腺嘧啶（T）。这种倾向可能是高度甲基化基因组中CpG缺乏的原因。