外源性5-羟色胺刺激大鼠胃泌素分泌的可能机制。

Possible mechanism of stimulation of gastrin secretion by exogenous serotonin in rats.

作者信息

Hierro J H, Sánchez-Barriga M J, Solana R, Requena F, Peña J

出版信息

Rev Esp Fisiol. 1980 Sep;36(3):285-90.

Abstract

The effect of 6-hydroxydopamine, propranolol, phentolamine, alpha-methyl-tyrosine and alpha-methyl-tyrosine plus propranolol on serotonin-stimulated gastrin secretion in rats has been examined. Gastrin secretion in response to administration of serotonin alone (10 mg/kg i.p.) was significantly reduced in rats pretreated with 6-hydroxydopamine or with propranolol. These results suggest that the effect of exogenous serotonin on gastrin secretion can be described as sympathomimetic and indirect. The serotonin-stimulated gastrin secretion was significantly enhanced by previous administration of phentolamine. Pretreatment with alpha-methyl-tyrosine also elevated serotonin-stimulated gastrin secretion, indicating that in the presence of diminished concentrations of the catecholamines, the influence of exogenous serotonin on secretion by G cells is increased. This enhancement in the serum gastrin levels was also reduced to a significant extent by simultaneous administration of propranolol, which suggested the activation of G-cell beta-adrenergic receptors after serotonin administration.

摘要

研究了6-羟基多巴胺、普萘洛尔、酚妥拉明、α-甲基酪氨酸以及α-甲基酪氨酸加普萘洛尔对大鼠血清素刺激胃泌素分泌的影响。单独给予血清素（10mg/kg腹腔注射）时，用6-羟基多巴胺或普萘洛尔预处理的大鼠胃泌素分泌显著减少。这些结果表明，外源性血清素对胃泌素分泌的影响可描述为拟交感神经作用和间接作用。预先给予酚妥拉明可显著增强血清素刺激的胃泌素分泌。用α-甲基酪氨酸预处理也可提高血清素刺激的胃泌素分泌，这表明在儿茶酚胺浓度降低的情况下，外源性血清素对G细胞分泌的影响增加。同时给予普萘洛尔也可在很大程度上降低血清胃泌素水平的这种升高，这表明血清素给药后G细胞β-肾上腺素能受体被激活。