Cooney T, Benediktsson H, Mukai K
Am J Surg Pathol. 1980 Oct;4(5):491-9. doi: 10.1097/00000478-198010000-00009.
A patient with clinical and biochemical evidence of ectopic ACTH production is described. Autopsy revealed endocrine tumors of bronchus and pancreas with metastases to the liver, kidney, abdominal lymph nodes, and bone. Immunohistochemical methods established that the bronchial and pancreatic tumors were separate primary neoplasms each with its own hormone production; and allowed us to determine that the bronchial carcinoid was the source of ACTH and gave rise to the liver metastases, and that insulin was present in the cells of the pancreatic islet cell tumor. These methods also revealed a mild C-cell hyperplasia of the thyroid gland. We wish to stress the importance of the immunoperoxidase method in the evaluation of this and similar polyendocrine cases.
本文描述了一位具有异位促肾上腺皮质激素（ACTH）分泌的临床和生化证据的患者。尸检发现支气管和胰腺内分泌肿瘤，并伴有肝、肾、腹部淋巴结和骨转移。免疫组织化学方法证实，支气管和胰腺肿瘤是各自独立产生激素的原发性肿瘤；并使我们能够确定支气管类癌是ACTH的来源并导致肝转移，且胰岛素存在于胰腺胰岛细胞瘤细胞中。这些方法还显示甲状腺存在轻度C细胞增生。我们希望强调免疫过氧化物酶法在评估此类及类似多内分泌病例中的重要性。
