Thorén-Tolling K, Stavenborn M
Nord Vet Med. 1978 Jan;30(1):24-29.
Two cases of congenital anomalies in the portal system in young dogs are described. Clinical findings such as poor general condition with chronic weight loss and failure to grow, signs of central nervous disease, are typical for the hepato-encephalopathy syndrome. Clinical and radiological examination revealed a small liver and in one dog large kidneys. Hematological data (hemoglobin, leukocytes and PCV) were normal but elevated bromosulphtalein retention was seen in both cases. Furthermore, low serumprotein, due to reduced albumin fraction, low urea-N and large amounts of ammoniumbiurate crystals in the urine are typical findings in portal anomalies with hepatoencephalopathy. In one dog hepatic insufficiency was due to a porta-cava shunt localized just outside the liver, and in the other dog an intrahepatic porta atresia was found with secondary fibrosis of the liver parenchyma. The liver was atrophic and the kidneys revealed chronic glomerulosclerosis. It is concluded that the clinical and pathological findings were results of vessel anomalies.
本文描述了两例幼犬门静脉系统先天性异常的病例。临床症状如全身状况不佳、慢性体重减轻和生长发育迟缓、中枢神经系统疾病体征,是肝性脑病综合征的典型表现。临床和放射学检查显示肝脏较小,其中一只狗的肾脏较大。血液学数据(血红蛋白、白细胞和红细胞压积)正常,但两例均可见溴磺酞钠潴留升高。此外,由于白蛋白部分减少导致血清蛋白降低、尿素氮降低以及尿中大量尿酸铵结晶,是伴有肝性脑病的门静脉异常的典型表现。一只狗的肝功能不全是由于肝外门静脉-腔静脉分流所致,另一只狗则发现肝内门静脉闭锁并伴有肝实质继发性纤维化。肝脏萎缩,肾脏显示慢性肾小球硬化。结论是临床和病理表现是血管异常的结果。