Karpas A, Worman C, Arno J, Nagington J
Br J Haematol. 1980 Jun;45(2):195-200. doi: 10.1111/j.1365-2141.1980.tb07138.x.
The histiocytes from a patient with sinus histiocytosis were tested for the presence of Epstein-Barr viral nuclear antigen (EBNA) before and after in vitro growth. On both occasions the histiocytes as well as the lymphocytes were EBNA negative. Likewise the profile of EBV viral capsid antibody (VCA) suggests that this virus is unlikely to be directly involved in the development of the disease. The maintenance of an unusually high level of antibodies to EBV and measles, both viruses which produce persistent infections, indicates that the humoral immune response is active. That a normal humoral response occurred in response to mumps virus during the same period suggests that a deficiency in the cell mediated immune response to the persistent viruses might be the reason for the abnormally high antibody levels. The fresh as well as the cultured histiocytes had only Fc receptors. The affected lymph node lymphocytes developed unusual large inclusion bodies following in vitro culture.
对一名窦性组织细胞增多症患者的组织细胞在体外培养前后进行了爱泼斯坦-巴尔病毒核抗原（EBNA）检测。在这两种情况下，组织细胞以及淋巴细胞的EBNA均为阴性。同样，EB病毒衣壳抗体（VCA）的检测结果表明，该病毒不太可能直接参与该疾病的发生发展。对EB病毒和麻疹病毒（这两种病毒都会产生持续性感染）的抗体水平异常高，这表明体液免疫反应活跃。同期对腮腺炎病毒产生了正常的体液反应，这表明对持续性病毒的细胞介导免疫反应缺陷可能是抗体水平异常高的原因。新鲜的和培养后的组织细胞仅具有Fc受体。受影响的淋巴结淋巴细胞在体外培养后形成了异常大的包涵体。
