腹内侧下丘脑的葡萄糖氧化不受胰岛素或哇巴因的影响，但会因四氧嘧啶处理而受到抑制。

Glucose oxidation in the ventromedial hypothalamus is not affected by insulin or ouabain but depressed by alloxan treatment.

作者信息

Brown D F, Viles J M

出版信息

Exp Brain Res. 1980;40(4):464-7. doi: 10.1007/BF00236155.

Abstract

Insulin is apparently not required for VMH glucose oxidation in vitro. Ouabain, an inhibitor of the Na-K pump ATPase, does not prevent VMH glucose oxidation in vitro. These data suggest (a) the VMH does not exhibit a cotransport phenomenon of glucose with the Na-K pump mechanism, and (b) glucose oxidation in the VMH is not insulin dependent. Alloxan-diabetes was induced to increase tissue insulin sensitivity. A comparison of glucose oxidation rates in alloxan-diabetic VMH tissue and normal VMH tissue, supplemented only with saline, indicated a highly significant (p < 0.001) depression of glucose oxidation in the alloxan-treated tissue. Cell membranes in the VMH are perhaps altered by alloxan.

摘要

体外实验中，腹内侧核（VMH）的葡萄糖氧化显然不需要胰岛素。哇巴因是钠钾泵ATP酶的抑制剂，在体外实验中并不阻止VMH的葡萄糖氧化。这些数据表明：（a）VMH不存在葡萄糖与钠钾泵机制的协同转运现象；（b）VMH中的葡萄糖氧化不依赖胰岛素。通过诱导产生四氧嘧啶糖尿病以提高组织对胰岛素的敏感性。比较四氧嘧啶糖尿病VMH组织和仅补充生理盐水的正常VMH组织中的葡萄糖氧化速率，结果表明，经四氧嘧啶处理的组织中葡萄糖氧化显著降低（p < 0.001）。四氧嘧啶可能改变了VMH中的细胞膜。