de Backer M, de Nutte N, Verbeelen D, Ducobu J, Six R, Corvilain J
Klin Wochenschr. 1980 Jul 1;58(13):689-94. doi: 10.1007/BF01478606.
Plasma immunoreactive parathyroid hormone level, urinary excretion of adenosine cyclic 3',5'-monophosphate (cyclic AMP) and the sensitivity of the renal tubule to calcium infusion and to parathyroid extract were investigated in a patient with nonfamilial hypophosphatemic osteomalacia. Plasma immunoreactive parathyroid hormone concentration was normal and basal urinary excretion of cyclic AMP was increased. Renal cortical adenylate cyclase, as measured by urinary cyclic AMP excretion, was certainly as sensitive to exogenous parathyroid extract as in normal subjects. After a previous calcium infusion, a greater parathyroid-hormone-sensitive component of phosphorus transport in the kidney was present than in two control subjects. Our results indicate that in nonfamilial hypophosphatemic osteomalacia the renal tubule could be hyperresponsive to parathyroid hormone.
对一名非家族性低磷性骨软化症患者的血浆免疫反应性甲状旁腺激素水平、尿中环磷酸腺苷（cAMP）的排泄以及肾小管对钙输注和甲状旁腺提取物的敏感性进行了研究。血浆免疫反应性甲状旁腺激素浓度正常，基础尿cAMP排泄增加。通过尿cAMP排泄测定的肾皮质腺苷酸环化酶对外源性甲状旁腺提取物的敏感性肯定与正常受试者相同。在先前的钙输注后，肾脏中磷转运的甲状旁腺激素敏感成分比两名对照受试者更多。我们的结果表明，在非家族性低磷性骨软化症中，肾小管可能对甲状旁腺激素反应过度。
