Fedorov V V
Neirofiziologiia. 1980;12(6):627-36.
The time course of spontaneous miniature end-plate potentials (MEPP) and currents (MEPC) was compared in fast and slow muscle fibres using extracellular focal recording or voltage-clamp technique. The mean values of the rise and decline half-time of MEPP and MEPC in slow fibres was 1.3-1.4 times as much as those in fast ones. A smaller difference was observed after AChE inhibition. Decay of the end-plate currents remained generally exponential and its rate depended on the membrane potential level. Distribution of different muscle fibres according to the time course of MEPP and MEPC in fast and slow muscles correlates with the content of the different fibre types identified on other properties. The possible factors controlling the time course of postsynaptic responses (AChE activity, the length of diffusional pathways, differences in the membrane passive electrical properties) and their significance in synapses of different types are discussed.
利用细胞外焦点记录或电压钳技术，比较了快肌纤维和慢肌纤维中自发微小终板电位（MEPP）和电流（MEPC）的时间进程。慢肌纤维中MEPP和MEPC的上升和下降半衰期的平均值是快肌纤维的1.3 - 1.4倍。在乙酰胆碱酯酶抑制后观察到较小的差异。终板电流的衰减通常仍呈指数形式，其速率取决于膜电位水平。根据快肌和慢肌中MEPP和MEPC的时间进程对不同肌纤维的分布与根据其他特性鉴定出的不同纤维类型的含量相关。讨论了控制突触后反应时间进程的可能因素（乙酰胆碱酯酶活性、扩散途径的长度、膜被动电学性质的差异）及其在不同类型突触中的意义。
