Reuber M D
Tumori. 1980 Jun 30;66(3):277-83. doi: 10.1177/030089168006600301.
B6C3F1 female mice fed an average dose of 3,000 ppm of perthane for 2 years developed a highly significant incidence of hepatocellular carcinomas of the liver. Male mice fed 2,500 ppm perthane had a slight increase of carcinoma of the liver. Some of the carcinomas were well-differentiated; however, most were poorly differentiated or undifferentiated. Perthane-treated mice also had well and poorly differentiated cholangiocarcinomas and carcinosarcomas, neoplasms not seen in control mice.
给雌性B6C3F1小鼠喂食平均剂量为3000 ppm的过氧三乙铅，持续2年，肝脏肝细胞癌的发病率显著升高。喂食2500 ppm过氧三乙铅的雄性小鼠肝癌发病率略有增加。部分癌组织分化良好；然而，大多数癌组织分化差或未分化。接受过氧三乙铅处理的小鼠还出现了分化良好和分化差的胆管癌及癌肉瘤，这些肿瘤在对照小鼠中未见到。
