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左旋咪唑对尿酸钠结晶吞噬后多形核白细胞溶酶体酶释放及细胞内cAMP和cGMP水平的影响。

Effect of levamisole on lysosomal enzyme release from polymorphonuclear leukocytes and intracellular levels of cAMP and cGMP after phagocytosis of monosodium urate crystals.

作者信息

Mikulíková D, Trnavský K

出版信息

Agents Actions. 1980 Sep;10(4):374-7. doi: 10.1007/BF01971443.

DOI:10.1007/BF01971443
PMID:6255776
Abstract

In order to study the influence of levamisole on lysosomal enzyme release, human polymorphonuclear (PMN) leukocytes were incubated with 0.5 mg/ml monosodium urate crystals. The release of neutral proteinase, beta glucuronidase, myeloperoxidase and lactic dehydrogenase as cytoplasmatic marker was measured. Preincubation of PMN with various concentrations of levamisole lasting 1 h resulted in a decrease of all enzymes released. Intracellular levels of both cyclic nucleotides--cAMP and cGMP--rose in PMN preincubated with levamisole, in comparison with untreated cells.

摘要

为了研究左旋咪唑对溶酶体酶释放的影响，将人多形核（PMN）白细胞与0.5mg/ml尿酸钠晶体一起孵育。测量了作为细胞质标志物的中性蛋白酶、β-葡萄糖醛酸酶、髓过氧化物酶和乳酸脱氢酶的释放。PMN与不同浓度的左旋咪唑预孵育1小时导致所有释放的酶减少。与未处理的细胞相比，用左旋咪唑预孵育的PMN中两种环核苷酸——cAMP和cGMP的细胞内水平升高。

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本文引用的文献

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Crystal-induced arthritis.晶体性关节炎
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Mechanisms of lysosomal enzyme release from human leukocytes. II. Effects of cAMP and cGMP, autonomic agonists, and agents which affect microtubule function.人白细胞溶酶体酶释放的机制。II. 环磷酸腺苷（cAMP）和环磷酸鸟苷（cGMP）、自主神经激动剂以及影响微管功能的药物的作用
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A protein binding assay for adenosine 3':5'-cyclic monophosphate.一种用于检测3':5'-环磷酸腺苷的蛋白质结合测定法。
Proc Natl Acad Sci U S A. 1970 Sep;67(1):305-12. doi: 10.1073/pnas.67.1.305.
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Nonphagocytic release of neutral protease and beta-glucuronidase from human neutrophils. Regulation by autonomic neurohormones and cyclic nucleotides.人中性粒细胞中性蛋白酶和β-葡萄糖醛酸酶的非吞噬性释放。自主神经激素和环核苷酸的调节作用。
Arthritis Rheum. 1974 Jan-Feb;17(1):25-36. doi: 10.1002/art.1780170106.
9
Mechanisms of lysosomal enzyme release from human leukocytes. I. Effect of cyclic nucleotides and colchicine.人白细胞溶酶体酶释放的机制。I. 环核苷酸和秋水仙碱的作用。
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Experientia. 1979 Apr 15;35(4):525-6. doi: 10.1007/BF01922748.