7，N，N-三甲基色胺：一种突触体血清素摄取的选择性抑制剂。
7,N,N-Trimethyltryptamine: a selective inhibitor of synaptosomal serotonin uptake.
作者信息
Glennon R A, Martin B, Johnson K M, End D
出版信息
Res Commun Chem Pathol Pharmacol. 1978 Jan;19(1):161-4.
PMID:625585
Abstract
7,N,N-Trimethyltryptamine (TMT) was synthesized and evaluated as an inhibitor of synaptosomal biogenic amine uptake in rat forebrain homogenates. In addition to inhibiting 3H-serotonin uptake (IC50 = 0.4 micrometer), TMT appears to be quite selective and is much less potent in blocking either 3H-norepinephrine or 3H-dopamine uptake (IC50 = 180 micrometer and 61 micrometer, respectively).
摘要
7，N，N - 三甲基色胺（TMT）被合成，并作为大鼠前脑匀浆中突触体生物胺摄取抑制剂进行评估。除了抑制3H - 血清素摄取（IC50 = 0.4微米）外，TMT似乎具有相当的选择性，在阻断3H - 去甲肾上腺素或3H - 多巴胺摄取方面效力要低得多（IC50分别为180微米和61微米）。
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