Feldman S A, Agoston S
Br J Anaesth. 1980 Dec;52(12):1199-1203. doi: 10.1093/bja/52.12.1199.
Neostigmine failed to modify the development of neuromuscular block in the presence of a high local concentration of tubocurarine. Only when the concentration of tubocurarine was reduced, and a suitable concentration gradient established between the receptor area and the plasma, did neostigmine increase the rate of recovery from the action of non-depolarizing neuromuscular blocking agents.
在局部筒箭毒碱浓度较高的情况下，新斯的明未能改变神经肌肉阻滞的发展。只有当筒箭毒碱浓度降低，且在受体区域和血浆之间建立了合适的浓度梯度时，新斯的明才会增加非去极化神经肌肉阻滞剂作用后的恢复速率。
