Palaic D, Farruggia P
Clin Exp Hypertens (1978). 1980;2(6):973-81. doi: 10.3109/10641968009037155.
Deoxycholic acid (0.01%) diminished the tissue response to angiotensin in rabbit aortic strips. A lower maximal response was obtained, but the affinity of angiotensin receptors did not change. Specific angiotensin receptor binding was measured in cell membrane fraction, solubilised fraction and pellet fraction after solubilization. The solubilised fraction showed threefold increase in receptor binding and was devoid of angiotensinase activity. The binding to pellet fraction after solubilization was increased or unchanged and contained the same angiotensinase activity as before solubilization. We conclude that it is possible to separate angiotensin receptor from cell membrane angiotensinase.
脱氧胆酸（0.01%）可减弱兔主动脉条对血管紧张素的组织反应。虽然获得了较低的最大反应，但血管紧张素受体的亲和力并未改变。在细胞膜部分、溶解部分和溶解后的沉淀部分测量了特异性血管紧张素受体结合情况。溶解部分的受体结合增加了三倍，且没有血管紧张素酶活性。溶解后与沉淀部分的结合增加或不变，并且含有与溶解前相同的血管紧张素酶活性。我们得出结论，有可能将血管紧张素受体与细胞膜血管紧张素酶分离。
