[钙、凝血酶及核苷酸（ADP、cAMP、cGMP）对血小板糖酵解及能量代谢的影响]
[Effect of calcium, thrombin and nucleotides (ADP, cAMP, cGMP) on blood platelet glycolysis and energy metabolism].
作者信息
Nikulin A A
出版信息
Farmakol Toksikol. 1980 Sep-Oct;43(5):585-90.
PMID:6256208
Abstract
It has been shown that ADP, thrombin, calcium, cAMP and cGMP induce changes in platelet metabolism. Aggregation inducers that inhibit the glycolytic enzymes decrease the content of pyruvate and ATP in platelets. The aggregation inhibitor, cAMP increases the activity of pyruvate kinase and the content of pyruvate and ATP in platelets. Cyclic AMP does not affect the activity of pyruvate kinase but raises the level of pyruvate and diminishes the content of ATP in platelets.
摘要
已表明，二磷酸腺苷（ADP）、凝血酶、钙、环磷酸腺苷（cAMP）和环磷酸鸟苷（cGMP）可诱导血小板代谢发生变化。抑制糖酵解酶的聚集诱导剂会降低血小板中丙酮酸和三磷酸腺苷（ATP）的含量。聚集抑制剂cAMP可增加丙酮酸激酶的活性以及血小板中丙酮酸和ATP的含量。环磷酸腺苷不影响丙酮酸激酶的活性，但会提高血小板中丙酮酸的水平并降低ATP的含量。
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