Snape W J
Gastroenterology. 1981 Mar;80(3):498-503.
Papaverine relaxes smooth muscle from various organ systems throughout the body. The purpose of this study was to determine the effects of papaverine on colonic smooth muscle from the transverse colon of the cat. Myoelectrical activity was recorded with monopolar glass pore electrodes. Papaverine was administered alone and simultaneously with bethanechol or the octapeptide of cholecystokinin. Higher concentrations of papaverine (10(-4) M, 10(-5) M) abolished both slow-wave activity and migrating spike bursts. Lower concentrations of papaverine (10(-6) M) had no effect on slow waves or the migrating spike burst. Bethanechol (10(-6) M) or OP-CCK (4 x 10(-9) M, 4 x 10(-10) M) stimulated spike activity (p < 0.001). Papaverine (10(-6) M had a minimal effect on the increase in spike activity that occurred after octapeptide of cholecystokinin in a concentration of 4 x 10(-10) M (p < 0.05). Papaverine had no effect on the stimulation of the colonic smooth muscle by 4 x 10(-10) M octapeptide of the colonic smooth muscle by 4 x 10(-9) M octapeptide of cholecystokinin. These studies show that (a) papaverine can inhibit smooth muscle myoelectrical activity, (b) papaverine is a potent inhibitor of cholinergic stimulation of colonic smooth muscle, but (c) papaverine has a minimal effect on octapeptide of cholecystokinin stimulation of the isolated colonic smooth muscle.
罂粟碱可使全身各器官系统的平滑肌松弛。本研究的目的是确定罂粟碱对猫横结肠结肠平滑肌的影响。采用单极玻璃微电极记录肌电活动。单独给予罂粟碱，并同时与氨甲酰甲胆碱或胆囊收缩素八肽合用。较高浓度的罂粟碱（10⁻⁴M、10⁻⁵M）可消除慢波活动和移行性锋电位爆发。较低浓度的罂粟碱（10⁻⁶M）对慢波或移行性锋电位爆发无影响。氨甲酰甲胆碱（10⁻⁶M）或八肽胆囊收缩素（4×10⁻⁹M、4×10⁻¹⁰M）刺激锋电位活动（p<0.001）。罂粟碱（10⁻⁶M）对浓度为4×10⁻¹⁰M的胆囊收缩素八肽后出现的锋电位活动增加影响最小（p<0.05）。罂粟碱对4×10⁻¹⁰M胆囊收缩素八肽刺激结肠平滑肌无影响，对4×10⁻⁹M胆囊收缩素八肽刺激结肠平滑肌也无影响。这些研究表明：（a）罂粟碱可抑制平滑肌肌电活动；（b）罂粟碱是结肠平滑肌胆碱能刺激的有效抑制剂；但（c）罂粟碱对胆囊收缩素八肽刺激离体结肠平滑肌的影响最小。
