[大肠杆菌K-12的生存力与可突变性以及DNA与蛋白质合成之间的平衡关系。III. 在胸苷剥夺期间，recB和polA基因缺陷的thy-细胞中DNA与蛋白质合成平衡的破坏与诱变及生存力之间的关系]

[Relation between Escherichia coli K-12 viability and mutability and the balance between DNA and protein synthesis. III. Relation between disruptions in the balance between DNA and protein synthesis and mutagenesis and viability during thymidine deprivation of thy- cells defective with respect to recB and polA genes].

作者信息

Fradkin G E, Aĭzenberg O A, Naumova L A, Rabinkova E V

出版信息

Genetika. 1980;16(7):1199-1203.

Abstract

The phenomenon of metabolic mutagenesis is found to be determined by stabilization of metabolic breaks in DNA chains, being linked with disbalance of intracellular synthesis of DNA and protein. The rate of metabolic mutagenesis observed in case of the DNA-protein synthesis disbalance due to thymine starvation is influenced by cell genotype. The lack of exonuclease V in recB-thy- cells decreases (reduces) the rate of metabolic mutagenesis and does not effect the viability. The lack of DNA polymerase I activity in polA-thy- cells causes a sharp increase in the metabolic mutagenesis rate and a parallel sharp drop in the survival under thymine starvation, as compared to cells with polA+thy- genotype.

摘要

发现代谢诱变现象是由DNA链中代谢断裂的稳定所决定的，这与细胞内DNA和蛋白质合成的失衡有关。在由于胸腺嘧啶饥饿导致DNA - 蛋白质合成失衡的情况下观察到的代谢诱变率受细胞基因型影响。recB - thy - 细胞中外切核酸酶V的缺失会降低代谢诱变率，并且不影响细胞活力。与具有polA + thy - 基因型的细胞相比，polA - thy - 细胞中DNA聚合酶I活性的缺失会导致代谢诱变率急剧增加，同时在胸腺嘧啶饥饿条件下存活率平行急剧下降。

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