Schaefer S D, Denton R A, Blend B L, Carder H M
Laryngoscope. 1980 Dec;90(12):2021-6. doi: 10.1288/00005537-198012000-00013.
The first case of malignant fibrous histiocytoma of the frontal sinus is reported. The aggressive nature of the tumor despite its relatively benign histologic pattern and value of electron microscopy are emphasized. Ultrastructural examination reveals a progression of several principal cell types, lending support to the multi-potent mesenchymal cell origin of these malignancies. These cells may have arisen from the supporting stroma of the ectodermally derived respiratory epithelium of the paranasal sinuses. Wide local excision is currently the primary mode of therapy. The value of radiation therapy or chemotherapy in this tumor in unproven.
报告了首例额窦恶性纤维组织细胞瘤。强调了该肿瘤尽管组织学形态相对良性但其侵袭性本质以及电子显微镜检查的价值。超微结构检查揭示了几种主要细胞类型的演变，支持了这些恶性肿瘤起源于多能间充质细胞的观点。这些细胞可能起源于鼻窦外胚层来源的呼吸上皮的支持性基质。广泛局部切除目前是主要的治疗方式。放射治疗或化疗在该肿瘤中的价值尚未得到证实。
