Botticelli L J, Wurtman R J
Nature. 1981 Jan 1;289(5793):75-6. doi: 10.1038/289075a0.
The activity of septo-hippocampal neurones is affected by the action on cholinergic perikarya in the septum of a variety of putative neurotransmitters, including substance P and beta-endorphin. (The latter is released in the septal region from neurones which originate in the medial basal hypothalamus.) It has also been reported that two other neuropeptides, corticotropin (ACTH1-24) and alpha-melanotropin (alpha-MSH), affect acetylcholine turnover in septo-hippocampal neurones in a manner that is not blocked by transection of the afferents to the hippocampus, from which it has been inferred that the neurotransmitters act directly on the hippocampus. We now describe experiments with corticotropin which show that the effect is rather the influence on septo-hippocampal cholinergic neurones of peptidergic neurones within the septum.
多种假定的神经递质，包括P物质和β-内啡肽，作用于隔区的胆碱能神经元胞体，会影响隔海马神经元的活性。（后者是由起源于下丘脑内侧基底部的神经元在隔区释放的。）也有报道称，另外两种神经肽，促肾上腺皮质激素（ACTH1 - 24）和α-促黑素（α-MSH），以一种不会因切断海马传入神经而被阻断的方式影响隔海马神经元中的乙酰胆碱周转，由此推断这些神经递质直接作用于海马。我们现在描述用促肾上腺皮质激素进行的实验，这些实验表明其作用更确切地说是隔区内肽能神经元对隔海马胆碱能神经元的影响。
