Simon Z, Vlad A, Ciureanu M, Motoc I, Holban S
Pol J Pharmacol Pharm. 1980 Mar-Apr;32(2):179-85.
Quantitative structure-activity relation for amino acid substitution analogues of the LH-RH decapeptide were established by means of the receptor site mapping procedure based upon minimal steric differences. For a series of 17 analogues of LH-RH, obtained by substitutions of the C-terminal Gly-NH2 residue, a corelation coefficient r = 0.93 was obtained, for a series of 7 analogues, obtained by substitutions of the Leu7 residue, r = 0.95 was obtained. The shape of the LH-RH receptor regions interacting with the C-terminal of the decapetide and with the Leu7-side chain is inferred from this study.
基于最小空间差异的受体位点映射程序，建立了促黄体生成激素释放激素（LH-RH）十肽氨基酸取代类似物的定量构效关系。对于通过C末端甘氨酰胺（Gly-NH2）残基取代获得的一系列17种LH-RH类似物，相关系数r = 0.93；对于通过亮氨酸7（Leu7）残基取代获得的一系列7种类似物，r = 0.95。从本研究中推断出与十肽C末端和Leu7侧链相互作用的LH-RH受体区域的形状。
