Bekhtereva E P
Probl Endokrinol (Mosk). 1980;26(6):42-5.
In experiments on mature female rats it was shown that L-DOPA administration restores normal ovulation in rats after the dorsal hippocampus destruction and related partial ovulation blockade. Pharmacological analysis after microinjections of alpha- and beta-adrenoblockers into the dorsal hippocampus region has shown that alpha- and beta-adrenoreception of the dorsal hippocampus plays a definite role in the regulation of gonadotropin secretion. However, the effect of phentolamine injection on the rat ovulatory reaction was less pronounced than under conditions of this hippocampus region destruction. The beta-adrenoblocker propranolol injected into the dorsal hippocampus inhibited compensatory hypertrophy of the ovaries in hemicastrated rats, decreased the hypophyseal FSH content and did not influence ovulation.
在对成年雌性大鼠的实验中发现，给予左旋多巴可使背侧海马体破坏及相关部分排卵阻滞后的大鼠恢复正常排卵。向背侧海马体区域微量注射α-和β-肾上腺素能阻滞剂后的药理学分析表明，背侧海马体的α-和β-肾上腺素能受体在促性腺激素分泌调节中起一定作用。然而，酚妥拉明注射对大鼠排卵反应的影响不如在该海马体区域破坏的情况下明显。向背侧海马体注射β-肾上腺素能阻滞剂普萘洛尔可抑制半侧卵巢切除大鼠卵巢的代偿性肥大，降低垂体促卵泡激素含量，且不影响排卵。
