Arner P, Wennlund A, Ostman J
Acta Endocrinol (Copenh). 1981 Jan;96(1):65-9. doi: 10.1530/acta.0.0960065.
The possibility of a relationship between the thyroid hormone level and the peripheral action of catecholamines was examined in 4 normal-weight and 19 obese euthyroid subjects as well as in 27 hyperthyroid subjects by comparing the serum thyroid hormone level and the in vitro effect of catecholamines on lipolysis and cyclic AMP accumulation in adipose tissue incubated with and without isopropyl noradrenaline (ISNA) or noradrenaline (NA). ISNA- and NA-induced rates of lipolysis and cyclic AMP production were significantly correlated with free thyroxine index (r = 0.63-0.74) and with the serum triiodothyronine level (r = 0.83-0.87). The thyroid hormone level was neither correlated with basal rate of lipolysis nor with basal cyclic AMP production (r < 0.2). These results suggest that the magnitude of catecholamine-induced cyclic AMP production by peripheral cells may be regulated by the level of circulating thyroid hormones. The effect of thyroid hormones on lipolysis appears to be specifically linked to the action of catecholamines.
通过比较血清甲状腺激素水平以及儿茶酚胺在有或无异丙基去甲肾上腺素（ISNA）或去甲肾上腺素（NA）存在的情况下对脂肪组织中脂肪分解和环磷酸腺苷（cAMP）积累的体外作用，研究了4名体重正常和19名甲状腺功能正常的肥胖受试者以及27名甲状腺功能亢进受试者甲状腺激素水平与儿茶酚胺外周作用之间的关系。ISNA和NA诱导的脂肪分解率及cAMP生成率与游离甲状腺素指数显著相关（r = 0.63 - 0.74），与血清三碘甲状腺原氨酸水平也显著相关（r = 0.83 - 0.87）。甲状腺激素水平与基础脂肪分解率及基础cAMP生成均无相关性（r < 0.2）。这些结果表明，外周细胞中儿茶酚胺诱导的cAMP生成量可能受循环甲状腺激素水平的调节。甲状腺激素对脂肪分解的作用似乎与儿茶酚胺的作用有特定联系。
