D'Angelo L J, Hierholzer J C, Holman R C, Smith J D
Am J Epidemiol. 1981 Jan;113(1):44-9. doi: 10.1093/oxfordjournals.aje.a113064.
During late 1977 and early 1978, 192 cases of epidemic keratoconjunctivitis occurred in a community in central Georgia. In 86 of these cases, the patient had been exposed to a single ophthalmologist's office (physician A) 3-22 days before onset of illness. Patients considered as cases were more likely to have had invasive ophthalmologic procedures than non-cases (p < 0.001), and a linear relationship existed between the number of procedures performed and the attack rate (r = 0.91, p < 0.05). Adenovirus type 8 (AV8) was identified as the responsible pathogen by culture and/or antibody determination for 20 of these patients. Group-specific AV hexon antigen and type specific dodecon antigen were identified in four of seven ophthalmic solutions obtained from physician A's office. The outbreak stopped after proper control techniques were initiated.
1977年末至1978年初，佐治亚州中部一个社区发生了192例流行性角结膜炎病例。其中86例患者在发病前3 - 22天曾去过一位眼科医生的诊所（医生A）。与非病例相比，被视为病例的患者更有可能接受过侵入性眼科手术（p < 0.001），并且所进行的手术数量与发病率之间存在线性关系（r = 0.91，p < 0.05）。通过培养和/或抗体检测，确定其中20例患者的病原体为8型腺病毒（AV8）。从医生A的诊所获得的七种眼科溶液中，有四种检测出了腺病毒群特异性六邻体抗原和型特异性十二聚体抗原。采取适当的控制措施后，疫情得到了控制。
