Wallace M, Fraser C D, Clements J A, Funder J W
Endocrinology. 1981 Jan;108(1):189-92. doi: 10.1210/endo-108-1-189.
Naloxone has a dose-dependent, significant anorectic effect when administered to normal rats, consistent with an antagonism of central or peripheral enkephalinergic or endorphinergic mechanisms. Mean levels of circulating immunoreactive beta-endorphin were similar in intact rats (0.5 ng/ml) and dexamethasone-treated adrenalectomized rats (0.5 ng/ml). In contrast, plasma levels were high in adrenalectomized rats with no replacement steroid (1.3 ng/ml) and in adrenalectomized rats given the mineralocorticoid deoxycorticosterone (0.9 ng/ml). In sharp distinction to the clear changes in circulating immunoreactive beta-endorphin produced by adrenalectomy and selective steroid replacement, no differences were seen in baseline food intake or anorectic response to naloxone. We conclude that a physiological role for circulating beta-endorphin in the regulation of food intake appears unlikely.
当给正常大鼠注射纳洛酮时，它会产生剂量依赖性的显著厌食效应，这与中枢或外周脑啡肽能或内啡肽能机制的拮抗作用一致。完整大鼠（0.5纳克/毫升）和地塞米松治疗的肾上腺切除大鼠（0.5纳克/毫升）中循环免疫反应性β-内啡肽的平均水平相似。相比之下，未补充类固醇的肾上腺切除大鼠（1.3纳克/毫升）和给予盐皮质激素脱氧皮质酮的肾上腺切除大鼠（0.9纳克/毫升）的血浆水平较高。与肾上腺切除术和选择性类固醇替代引起的循环免疫反应性β-内啡肽的明显变化形成鲜明对比的是，在基线食物摄入量或对纳洛酮的厌食反应方面未观察到差异。我们得出结论，循环β-内啡肽在食物摄入调节中的生理作用似乎不太可能。
