DeFeudis F V
Neurochem Res. 1980 Oct;5(10):1047-68. doi: 10.1007/BF00966163.
Muscimol has been used to increase our knowledge of central GABAergic systems, CNS physiology, and behavior. Some studies concerning the neurophysiological and behavioral effects of muscimol and its analogs have been reviewed and analyzed. In vivo iontophoretic studies have greatly increased our knowledge of the active conformation(s) adopted by GABA during its interaction with neuronal synaptic (or extrasynaptic) receptors, and behavioral studies have supported the notion that central GABAergic systems might be involved in convulsions, extrapyramidal functions, and other behaviors. However, behavioral studies with muscimol remain difficult to interpret in terms of central GABAergic systems, especially since muscimol is extensively metabolized and since it appears to interact with membrane sites other than GABA receptors. Muscimol does not appear to be useful for reversing human neurologic-psychiatric disorders.
蝇蕈醇已被用于增进我们对中枢γ-氨基丁酸能系统、中枢神经系统生理学和行为的了解。一些关于蝇蕈醇及其类似物的神经生理学和行为学效应的研究已得到综述和分析。体内离子电泳研究极大地增进了我们对γ-氨基丁酸在与神经元突触（或突触外）受体相互作用时所采取的活性构象的了解，而行为学研究支持了中枢γ-氨基丁酸能系统可能参与惊厥、锥体外系功能及其他行为的观点。然而，关于蝇蕈醇的行为学研究在中枢γ-氨基丁酸能系统方面仍难以解释，特别是因为蝇蕈醇会被广泛代谢，而且它似乎与γ-氨基丁酸受体以外的膜位点相互作用。蝇蕈醇似乎对逆转人类神经精神疾病并无用处。
