乙醇对培养神经细胞中超氧化物歧化酶活性的影响。
Effect of ethanol on superoxide dismutase activity in cultured neural cells.
作者信息
Ledig M, M'Paria J R, Louis J C, Fried R, Mandel P
出版信息
Neurochem Res. 1980 Nov;5(11):1155-62. doi: 10.1007/BF00964895.
PMID:6258092
Abstract
Superoxide dismutase (EC 1.15.1.1) activity was investigated in several types of neural cells cultivated in the presence of 100 mM ethanol. Superoxide dismutase was inhibited by acute treatment with ethanol. Chronic treatment with ethanol specifically inhibited superoxide dismutase in glial cells. In all instances withdrawal of ethanol produced a quick return to control values. Inhibition of superoxide dismutase by ethanol may increase toxic oxygen radicals in nervous tissue.
摘要
在100 mM乙醇存在的情况下培养的几种神经细胞中研究了超氧化物歧化酶（EC 1.15.1.1）的活性。乙醇急性处理可抑制超氧化物歧化酶。乙醇慢性处理特异性抑制神经胶质细胞中的超氧化物歧化酶。在所有情况下，撤除乙醇后酶活性迅速恢复到对照值。乙醇对超氧化物歧化酶的抑制作用可能会增加神经组织中的有毒氧自由基。
Zotero 插件