[抗坏血酸和燕麦多酚对四氧嘧啶糖尿病大鼠肝脏线粒体呼吸及氧化磷酸化的影响]
[Effect of ascorbic acid and oat polyphenols on respiration and oxidative phosphorylation in liver mitochondria in alloxan diabetic rats].
作者信息
Shamraĭ E F, Stroevaia L N, Beletskaia T A
出版信息
Ukr Biokhim Zh (1978). 1978 Jan-Feb;50(1):50-2.
30 mg of ascorbic acid and 80 mg of dry oats extracts were administered to rats with alloxan diabetes during a day per 1 kg of live weight. Administration of these preparations during 6, 12 and 24 days prevents the uncoupling action of respiration and oxidative phosphorylation, that was observed in the rats with alloxan diabetes which were not given ascorbic acid and oats polyphenols. The P/O coefficient on the alloxan diabetes rats on the 6, 12 and 24 days was 1.32 +/- 0.027; 1.26 +/- 0.013; 1.22 +/- 0.18, respectively; in the rats which were given ascorbic acid and oats polyphenols to P/O coefficient was 1.85 +/- 0,026, 1.80 +/- 0.024 and 1.75 +/- 0.028, respectively.
以每千克活重每天向四氧嘧啶糖尿病大鼠给予30毫克抗坏血酸和80毫克干燕麦提取物。在第6、12和24天给予这些制剂可防止在未给予抗坏血酸和燕麦多酚的四氧嘧啶糖尿病大鼠中观察到的呼吸解偶联作用和氧化磷酸化。在第6、12和24天，四氧嘧啶糖尿病大鼠的P/O系数分别为1.32±0.027；1.26±0.013；1.22±0.18；给予抗坏血酸和燕麦多酚的大鼠的P/O系数分别为1.85±0.026、1.80±0.024和1.75±0.028。
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