Bellet M, Elghozi J L
Nouv Presse Med. 1980 May 10;9(21):1503-8.
The discovery of opiate receptors has resulted in the isolation of endogenous morphinomimetics called endorphins. The enkephalins, which are pentapeptides, are located diffusely within the brain and are thought to act locally as neuromodulators for the release of noradrenaline, dopamine and substance P. beta-endorphin, a peptide with 31 aminoacids, is released from the pituitary with ACTH during stress. The peptide sequency of the common precursor of these hormones, pro-opiocortin, is now established.
阿片受体的发现导致了内源性类吗啡物质即内啡肽的分离。脑啡肽是一种五肽，广泛分布于脑内，被认为作为神经调质局部作用于去甲肾上腺素、多巴胺及P物质的释放。β-内啡肽是一种含31个氨基酸的肽，在应激状态下与促肾上腺皮质激素一起从垂体释放。这些激素的共同前体——阿片促皮质素原的肽序列现已确定。
