Ormsbee H S, Telford G L, Suter C M, Wilson P D, Mason G R
Am J Physiol. 1981 Feb;240(2):G141-6. doi: 10.1152/ajpgi.1981.240.2.G141.
This study quantitatively evaluated the characteristics of the aboral propagation of the canine migrating motor complex (MMC). Five conscious dogs were implanted with extraluminal force transducers along the small intestine. After constructing a 30-cm Thirty-Vella loop of jejunum, 56 of 91 activity fronts were outside the tolerance limits for propagation from the proximal intestine to the loop established in the same dogs before operation. Similarly, 44 of 109 activity fronts were outside the tolerance limits for propagation from the loop to the distal intestine. After surgery, the propagation time from the proximal jejunum to the loop was significantly increased, and activity fronts were observed to originate in the loop and in the intestine distal to the anastomosis. Our study indicates that the hypothesis that extrinsic nerves alone control the migration of the MMC is incomplete. We suggest that the extrinsic and the intrinsic innervation of the gastrointestinal tract are both required for the precise pattern of the migration of the MMC.
本研究定量评估了犬移行性运动复合波（MMC）向口外传播的特征。对5只清醒犬沿小肠植入腔外力传感器。构建一个30厘米长的空肠Thirty-Vella袢后，91个活动波锋中有56个超出了术前在同一只犬身上确定的从近端肠段向该袢传播的耐受极限。同样，109个活动波锋中有44个超出了从该袢向远端肠段传播的耐受极限。术后，从近端空肠到该袢的传播时间显著增加，并且观察到活动波锋起源于该袢以及吻合口远端的肠段。我们的研究表明，仅由外在神经控制MMC移行的假说是不完整的。我们认为，胃肠道的外在和内在神经支配对于MMC精确的移行模式都是必需的。
