Kent R B, van Heerden J A, Weiland L H
Ann Surg. 1981 Feb;193(2):185-90. doi: 10.1097/00000658-198102000-00010.
In nonfunctioning islet cell tumors of the pancreas, hormone production is not clinically evident. This type of tumor constituted 15% of all islet cell tumors seen at the Mayo Clinic from 1960 through 1978. Although identical to functioning islet cell tumors embryologically and histologically, the nonfunctioning tumors differ in presentation, location, size, and rate of malignancy. At admission to the hospital, patients often have pain or jaundice due to a large, solid, solitary lesion that occurs most commonly in the head of the pancreas. Extended survival is not excluded by the high malignancy rate (92%) of these slow-growing tumors. The survival rates at three and five years were 60% and 44%, respectively, even though most patients had metastatic disease at the time of exploration.
在胰腺无功能性胰岛细胞瘤中，激素分泌在临床上并不明显。1960年至1978年间，这类肿瘤在梅奥诊所所见的所有胰岛细胞瘤中占15%。尽管无功能性肿瘤在胚胎学和组织学上与功能性胰岛细胞瘤相同，但在临床表现、位置、大小和恶性率方面存在差异。入院时，患者常因胰腺头部最常见的大的实性孤立性病变而出现疼痛或黄疸。这些生长缓慢的肿瘤恶性率较高（92%），但并不排除长期生存。即使大多数患者在探查时已有转移性疾病，其三年和五年生存率分别为60%和44%。
