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1
Effect of compound D-600 (methoxyverapamil) on gluconeogenesis and on acceleration of the process by alpha-adrenergic stimuli in rat kidney tubules.化合物D - 600（甲氧基维拉帕米）对大鼠肾小管糖异生及α - 肾上腺素能刺激加速该过程的影响。
Biochem J. 1980 Aug 15;190(2):283-91. doi: 10.1042/bj1900283.
2
Evidence that catecholamines stimulate renal gluconeogenesis through an alpha 1-type of adrenoceptor.儿茶酚胺通过α1型肾上腺素能受体刺激肾糖异生的证据。
Biochem J. 1980 Jul 15;190(1):119-23. doi: 10.1042/bj1900119.
3
Hormonal control of gluconeogenesis in tubule fragments from renal cortex of fed rats. Effects of alpha-adrenergic stimuli, glucagon, theophylline and papaverine.进食大鼠肾皮质肾小管片段中糖异生的激素调控。α-肾上腺素能刺激、胰高血糖素、茶碱和罂粟碱的作用。
Biochem J. 1977 Oct 15;168(1):33-42. doi: 10.1042/bj1680033.
4
Ouabain and K+ removal blocks alpha-adrenergic stimulation of gluconeogenesis in tubule fragments from fed rats.哇巴因和钾离子去除可阻断喂食大鼠肾小管片段中α-肾上腺素能对糖异生的刺激作用。
FEBS Lett. 1979 Oct 1;106(1):189-92. doi: 10.1016/0014-5793(79)80725-5.
5
Effect of the Na+ ionophore monensin on basal and noradrenaline stimulated gluconeogenesis in rat renal tubule fragments.钠离子载体莫能菌素对大鼠肾小管片段基础及去甲肾上腺素刺激的糖异生作用的影响。
FEBS Lett. 1981 Nov 16;134(2):183-4. doi: 10.1016/0014-5793(81)80597-2.
6
Gluconeogenesis in guinea pig renal tubule fragments--effects of noradrenaline, 3':5' cyclic AMP and angiotensin II.
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1983;74(2):409-12. doi: 10.1016/0742-8413(83)90123-8.
7
Hormonal regulation of renal gluconeogenesis in isolated tubule fragments.
Curr Probl Clin Biochem. 1976;6:202-13.
8
A study of regulation of gluconeogenesis and the supply of cytosolic reducing equivalents for lactate formation in rat kidney-cortical-tubule fragments incubated with pyruvate.一项关于丙酮酸孵育大鼠肾皮质小管片段中糖异生调节及乳酸生成的胞质还原当量供应的研究。
Biochem J. 1978 Jul 15;174(1):131-42. doi: 10.1042/bj1740131.
9
Metabolism of isolated kidney tubules. Independent actions of catecholamines on renal cyclic adenosine 3':5'-monophosphate levels and gluconeogenesis.离体肾小管的代谢。儿茶酚胺对肾环磷酸腺苷水平和糖异生的独立作用。
Eur J Biochem. 1975 Mar 17;52(2):283-90. doi: 10.1111/j.1432-1033.1975.tb03996.x.
10
Stimulation of renal gluconeogenesis by verapamil and D-600.维拉帕米和D - 600对肾糖异生的刺激作用。
Biochem Pharmacol. 1977 Jun 1;26(11):1089-91. doi: 10.1016/0006-2952(77)90251-9.

引用本文的文献

1
[Leu]enkephalin stimulates carbohydrate metabolism in isolated hepatocytes and kidney tubule fragments by interaction with angiotensin II receptors.亮氨酸脑啡肽通过与血管紧张素II受体相互作用，刺激离体肝细胞和肾小管碎片中的碳水化合物代谢。
Biochem J. 1989 Feb 1;257(3):705-10. doi: 10.1042/bj2570705.

本文引用的文献

1
EFFECT OF METAL IONS ON IN VITRO GLUCONEOGENESIS IN RAT KIDNEY CORTEX SLICES.金属离子对大鼠肾皮质切片体外糖异生的影响。
Am J Physiol. 1965 May;208:842-6. doi: 10.1152/ajplegacy.1965.208.5.841.
2
Renal gluconeogenesis. The effect of diet on the gluconeogenic capacity of rat-kidney-cortex slices.肾糖异生。饮食对大鼠肾皮质切片糖异生能力的影响。
Biochem J. 1963 Jan;86(1):22-7. doi: 10.1042/bj0860022.
3
Evidence that catecholamines stimulate renal gluconeogenesis through an alpha 1-type of adrenoceptor.儿茶酚胺通过α1型肾上腺素能受体刺激肾糖异生的证据。
Biochem J. 1980 Jul 15;190(1):119-23. doi: 10.1042/bj1900119.
4
The interrelationship of the concentration of hydrogen ions, bicarbonate ions, carbon dioxide and calcium ions in the regulation of renal gluconeogenesis in the rat.大鼠肾糖异生调节中氢离子、碳酸氢根离子、二氧化碳和钙离子浓度的相互关系。
Biochem J. 1973 Nov;136(3):445-53. doi: 10.1042/bj1360445.
5
Ioni control of renal gluconeogenesis. I. The interrelated effect of calcium and hydrogen ions.离子对肾糖异生的控制。I. 钙和氢离子的相互关联作用。
Biochim Biophys Acta. 1973 Jun 20;313(1):17-31. doi: 10.1016/0304-4165(73)90185-2.
6
Calcium and energy requirements for K + release mediated by the epinephrine -receptor in rat parotid slices.大鼠腮腺切片中肾上腺素受体介导的钾离子释放所需的钙和能量
J Biol Chem. 1973 Jan 10;248(1):369-72.
7
Metabolism of isolated kidney tubules. Oxygen consumption, gluconeogenesis and the effect of cyclic nucleotides in tubules from starved rats.离体肾小管的代谢。饥饿大鼠肾小管的耗氧量、糖异生作用及环核苷酸的影响。
Hoppe Seylers Z Physiol Chem. 1971 Oct;352(10):1319-28. doi: 10.1515/bchm2.1971.352.2.1319.
8
Stimulation of renal gluconeogenesis by verapamil and D-600.维拉帕米和D - 600对肾糖异生的刺激作用。
Biochem Pharmacol. 1977 Jun 1;26(11):1089-91. doi: 10.1016/0006-2952(77)90251-9.
9
Hormonal control of gluconeogenesis in tubule fragments from renal cortex of fed rats. Effects of alpha-adrenergic stimuli, glucagon, theophylline and papaverine.进食大鼠肾皮质肾小管片段中糖异生的激素调控。α-肾上腺素能刺激、胰高血糖素、茶碱和罂粟碱的作用。
Biochem J. 1977 Oct 15;168(1):33-42. doi: 10.1042/bj1680033.
10
Ouabain and K+ removal blocks alpha-adrenergic stimulation of gluconeogenesis in tubule fragments from fed rats.哇巴因和钾离子去除可阻断喂食大鼠肾小管片段中α-肾上腺素能对糖异生的刺激作用。
FEBS Lett. 1979 Oct 1;106(1):189-92. doi: 10.1016/0014-5793(79)80725-5.

化合物D - 600（甲氧基维拉帕米）对大鼠肾小管糖异生及α - 肾上腺素能刺激加速该过程的影响。

Effect of compound D-600 (methoxyverapamil) on gluconeogenesis and on acceleration of the process by alpha-adrenergic stimuli in rat kidney tubules.

作者信息

Saggerson E D, Carpenter C A

出版信息

Biochem J. 1980 Aug 15;190(2):283-91. doi: 10.1042/bj1900283.

DOI:10.1042/bj1900283
PMID:6258565
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1162092/
Abstract
  1. Tubule fragments were isolated from renal cortex of fed rats and glucose formation was measured after incubation with 5 mM-sodium lactate. 20 Compound D-600 (10-100 microM) decreased gluconeogenesis from lactate. This inhibition of the process by compound D-600 increased with increasing extracellular Ca2+ concentration, was overridden by noradrenaline and diminished by starvation for 24 h. 3. Inhibition of lactate-supported gluconeogenesis by compound D-600 was not prevented by the alpha 1-adrenoceptor antagonist thymoxamine. 4. Compound D-600 had little effect on gluconeogenesis from 2-oxoglutarate and increased gluconeogenesis from succinate. 5. Compound D-600 opposed stimulation of gluconeogenesis by noradrenaline or oxymetazoline (a selective alpha-adrenoceptor agonist) in a manner suggesting that compound D-600 is an alpha-adrenoceptor blocker. Oxymetazoline was more sensitive than noradrenaline to blockade by both compound D-600 and by the conventional alpha-adrenoceptor antagonist phentolamine. Noradrenaline became more sensitive to blockade by compound D-600 when extracellular Ca2+ was decreased. 6. Compound D-600 did not block stimulation of gluconeogenesis by angiotensin or cyclic AMP.
摘要

  1. 从喂食大鼠的肾皮质中分离出肾小管片段，在与5 mM乳酸钠孵育后测量葡萄糖生成量。20化合物D - 600（10 - 100 microM）可降低由乳酸生成葡萄糖的过程。化合物D - 600对该过程的抑制作用随细胞外Ca2 +浓度升高而增强，去甲肾上腺素可消除这种抑制作用，饥饿24小时可使其减弱。

  2. 化合物D - 600对乳酸支持的糖异生作用的抑制不能被α1 - 肾上腺素能受体拮抗剂噻吗洛尔阻止。

  3. 化合物D - 600对由2 - 氧代戊二酸生成葡萄糖的过程影响很小，却增加了由琥珀酸生成葡萄糖的过程。

  4. 化合物D - 600以一种表明其为α - 肾上腺素能受体阻滞剂的方式对抗去甲肾上腺素或奥昔麻黄碱（一种选择性α - 肾上腺素能受体激动剂）对糖异生的刺激作用。奥昔麻黄碱比去甲肾上腺素对化合物D - 600和传统α - 肾上腺素能受体拮抗剂酚妥拉明的阻断作用更敏感。当细胞外Ca2 +减少时，去甲肾上腺素对化合物D - 600的阻断作用变得更敏感。

  5. 化合物D - 600不阻断血管紧张素或环磷酸腺苷对糖异生的刺激作用。