外周乙酰胆碱合成抑制剂C10二氯醇的抗震颤作用
Anti-tremor action of C10Dichol, a peripheral acetylcholine synthesis inhibitor.
作者信息
Das M, Ganguly D K, Vedasiromoni J R
出版信息
Br J Pharmacol. 1980;71(1):349-53. doi: 10.1111/j.1476-5381.1980.tb10946.x.
Abstract
1 Anti-tremor action of decamethylene bis-(hydroxyethyl)-dimethylammonium bromide (C10Dichol), a peripheral acetylcholine synthesis inhibitor, was investigated. 2 C10Dichol inhibited tremor induced by oxotremorine, nicotine and physostigmine and afforded partial protection from physostigmine-induced mortality in mice. 3 In non-paralysing doses, C10Dichol antagonized the neuromuscular effects of oxotremorine, nicotine and physostigmine. 4 Prior administration of C10Dichol failed to prevent tremor and neuromuscular paralysis induced by harmine and arecoline. 5 In the absence of any antimuscarinic property of C10Dichol, its neuromuscular effects appeared to be casually related to its anti-tremor action. 6 This study reveals a possibility for the development of peripherally acting anti-Parkinson drugs.
摘要
- 研究了外周乙酰胆碱合成抑制剂十亚甲基双（羟乙基）二甲基溴化铵（C10Dichol）的抗震颤作用。2. C10Dichol抑制了由氧化震颤素、尼古丁和毒扁豆碱诱导的震颤，并对毒扁豆碱诱导的小鼠死亡提供了部分保护。3. 在非麻痹剂量下，C10Dichol拮抗了氧化震颤素、尼古丁和毒扁豆碱的神经肌肉效应。4. 预先给予C10Dichol未能预防由 harmine 和槟榔碱诱导的震颤和神经肌肉麻痹。5. 在C10Dichol没有任何抗毒蕈碱特性的情况下，其神经肌肉效应似乎与其抗震颤作用偶然相关。6. 这项研究揭示了开发外周作用抗帕金森病药物的可能性。
相似文献
1
Anti-tremor action of C10Dichol, a peripheral acetylcholine synthesis inhibitor.外周乙酰胆碱合成抑制剂C10二氯醇的抗震颤作用
Br J Pharmacol. 1980;71(1):349-53. doi: 10.1111/j.1476-5381.1980.tb10946.x.
2
Effects of some polymethylene bis(hydroxyethyl)dimethylammonium salts on neuromuscular transmission.某些聚亚甲基双（羟乙基）二甲基铵盐对神经肌肉传递的影响。
Br J Pharmacol Chemother. 1965 Oct;25(2):392-404. doi: 10.1111/j.1476-5381.1965.tb02058.x.
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[The effect of substances specifically depressing acetylcholine synthesis on the action of pharmacologically choline positive agents].[特异性抑制乙酰胆碱合成的物质对药理学上胆碱阳性药物作用的影响]
Biull Eksp Biol Med. 1968 May;65(5):79-81.
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Antioxotremorine action of propranolol.普萘洛尔的抗震颤素作用。
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Effects of some polymethylene bis(hydroxyethyl) dimethylammonium compounds on acetylcholine synthesis.某些聚亚甲基双（羟乙基）二甲基铵化合物对乙酰胆碱合成的影响。
Br J Pharmacol. 1971 May;42(1):78-87. doi: 10.1111/j.1476-5381.1971.tb07088.x.
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Tremorine-oxotremorine-induced tremor, hypothermia and analgesia, and physostigmine toxicity, in mice after pretreatment with beta-adrenoceptor antagonists.
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Antinicotinic action of benzyltrimethylammonium bromide (BTM).溴化苄基三甲基铵（BTM）的抗烟碱作用。
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Nicotine pretreatment diminished physostigmine-induced tremor in rats.
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Effects of some polymethylene bis(hydroxyethyl)dimethylammonium salts on neuromuscular transmission.某些聚亚甲基双（羟乙基）二甲基铵盐对神经肌肉传递的影响。
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