Dingledine R, Somjen G
Brain Res. 1981 Feb 23;207(1):218-22. doi: 10.1016/0006-8993(81)90697-1.
'Population' afferent spike and 'population' EPSP were recorded with extracellular microelectrodes in slices of hippocampal tissue maintained in vitro. Calcium concentration was changed in the bathing solution, and calcium activity ([Ca2+]0) was measured in interstitial fluid of the slice with ion-selective microelectrodes. Synaptic transfer was a non-linear continuous function of [Ca2+]0. Deviation of [Ca2+]0 by 0.1 mM from the 1.2 mM control level caused a change of approximately 15% in the slope of the input-output function.
在体外维持的海马组织切片中，用细胞外微电极记录“群体”传入峰电位和“群体”兴奋性突触后电位。改变灌流液中的钙浓度，并用离子选择性微电极测量切片间质液中的钙活性（[Ca2+]0）。突触传递是[Ca2+]0的非线性连续函数。[Ca2+]0从1.2 mM对照水平偏离0.1 mM会导致输入-输出函数斜率发生约15%的变化。
