Lewis D V
Brain Res. 1981 Feb 23;207(1):234-8. doi: 10.1016/0006-8993(81)90700-9.
Diphenylhydantoin (DPH) has been shown to prolong the repolarization phase of action potentials in Aplysia and to reduce the spike after hyperpolarization. We voltage-clamped somata of Aplysia giant neurons and measured the action potential currents to determine what alterations might be responsible for the prolonged repolarization and reduced undershoot. DPH did not affect the peak inward current; however, it did reversibly reduce the outward current at concentrations of 38 microM or greater. The data indicate that DPH reduced the voltage sensitive potassium conductance rather than the 'A' current or the calcium activated potassium conductance. These changes in outward current would explain the prolonged action potentials and reduced afterhypolarization seen with DPH in Aplysia.
已证实苯妥英（DPH）可延长海兔动作电位的复极化阶段，并减少超极化后的锋电位。我们对海兔巨型神经元的胞体进行电压钳制，并测量动作电位电流，以确定哪些改变可能导致复极化延长和超极化后电位减小。DPH不影响内向电流峰值；然而，在浓度为38 microM或更高时，它确实可逆地降低外向电流。数据表明，DPH降低了电压敏感性钾电导，而不是“A”电流或钙激活钾电导。外向电流的这些变化可以解释在海兔中观察到的DPH导致的动作电位延长和超极化后电位减小。
