Clavequin M C, Bugnon C, Lenys D
C R Seances Soc Biol Fil. 1980;174(6):1021-33.
The effects of several drugs upon normal and asthenospermic human sperms were tested: cyclic AMP significantly and constantly increased the rate of motile spermatozoa in most samples having an initial motility rate between 20 and 60%. ATP kept up high the motility rate, particularly in sperm displaying the highest initial motility. Other drugs (glycolytic substrates, pyruvate, ADP, AMP, caffeine had inconstant effects upon a few sperms. None drug was efficient upon sperms with initial motility rate lower than 20%; this was probably due to important lesions of the locomotor apparatus of the spermatozoa, as shown by electron microscopy investigations.
环磷酸腺苷（cyclic AMP）显著且持续地提高了大多数初始活力率在20%至60%之间的样本中活动精子的比例。三磷酸腺苷（ATP）维持了较高的活力率，特别是在初始活力最高的精子中。其他药物（糖酵解底物、丙酮酸、二磷酸腺苷（ADP）、一磷酸腺苷（AMP）、咖啡因）对少数精子有不稳定的影响。没有一种药物对初始活力率低于20%的精子有效；这可能是由于精子运动装置的严重损伤，电子显微镜研究表明了这一点。
