Kinoshita F, Nakai Y, Katakami H, Kato Y, Imura H
Endocrinology. 1981 Apr;108(4):1272-5. doi: 10.1210/endo-108-4-1272.
The role of brain catecholamines in controlling tonic LH secretion was studied in unanesthesized, freely moving, ovariectomized rats. Pretreatment with reserpine (10 mg/kg), given 24 h before the experiment, significantly suppressed pulsatile LH secretion in these rats. Intraperitoneal administration of clonidine (1 mg/kg), an alpha-adrenergic stimulating agent, significantly raised plasma LH levels in reserpine-treated rats. On the other hand, the administration of apomorphine (1.5 mg/kg), a dopamine receptor-stimulating agent, had no effect on the plasma LH levels. These findings suggest an excitatory role of noradrenaline, operating through alpha-adrenergic receptors, in pulsatile LH secretion in ovariectomized rats.
在未麻醉、自由活动的去卵巢大鼠中，研究了脑内儿茶酚胺在控制促黄体生成素（LH）基础分泌中的作用。在实验前24小时给予利血平（10毫克/千克）预处理，可显著抑制这些大鼠的LH脉冲式分泌。腹腔注射可乐定（1毫克/千克），一种α-肾上腺素能兴奋剂，可显著提高利血平处理大鼠的血浆LH水平。另一方面，注射阿扑吗啡（1.5毫克/千克），一种多巴胺受体兴奋剂，对血浆LH水平没有影响。这些发现表明，去甲肾上腺素通过α-肾上腺素能受体发挥兴奋作用，参与去卵巢大鼠LH的脉冲式分泌。
