Savoie S, Forest M G, Bourel B, Haour F, Saez J M, Collu R, Bertrand J, Ducharme J R
Horm Res. 1980;13(3):186-95. doi: 10.1159/000179286.
Testicular response to human chorionic gonadotropin (hCG) was studied in male lambs. Adenosine 3':5'-cyclic monophosphate (cAMP), testosterone (T), delta 4-androstenedione and 17 alpha-hydroxyprogesterone content and cAMP and T production by dispersed interstitial cells were assessed in control and hCG-pretreated animals. Plasma T levels increased after hCG at 1, 4 and 8 weeks. Increments in the testicular content of cAMP, delta 4-androstenedione, and T were greater at 8 weeks and that of 17 alpha-hydroxyprogesterone and 125I-hCG binding to dispersed interstitial cells were identical at all ages. cAMP and T production by dispersed interstitial cells from nonstimulated animals and the response to hCG and choleratoxin were similar in all lambs. In contrast, cAMP and T production were higher at 1 week only in animals pretreated with hCG in vivo. These data are compatible with hCG-induced desensitization at 4 and 8 weeks.
在雄性羔羊中研究了睾丸对人绒毛膜促性腺激素（hCG）的反应。评估了对照动物和经hCG预处理的动物中3':5'-环磷酸腺苷（cAMP）、睾酮（T）、Δ4-雄烯二酮和17α-羟孕酮的含量，以及分散的间质细胞产生cAMP和T的情况。在1周、4周和8周时，hCG处理后血浆T水平升高。8周时，睾丸中cAMP、Δ4-雄烯二酮和T的含量增加幅度更大，而17α-羟孕酮的含量以及125I-hCG与分散间质细胞的结合在所有年龄段均相同。所有羔羊中，未受刺激动物分散的间质细胞产生cAMP和T的情况以及对hCG和霍乱毒素的反应相似。相比之下，仅在体内经hCG预处理的动物中，1周时cAMP和T的产生量更高。这些数据与4周和8周时hCG诱导的脱敏作用相符。
